The Galleria Regionale collection housed in Palazzo Bellomo in Siracusa, Sicily comprises a series of valuable items dating from the Byzantine period to the late 19th century. With a variety of heterogeneous origins, they bear witness to a wealth of local art and, more generally, to the history of culture and changing tastes. The displays in the rooms of the medieval Palazzo Parisio and Palazzo Bellomo have been deliberately arranged to suit their setting. Each piece has an artistic value in its own right, but is also an integral part of a process of enhancement, in terms of both time and space, to the context which produced it. The guide, with its colour illustrations, is a companion volume to an itinerary around the museum’s exhibition, with a description of the works which includes their historical background, providing a colourful pathway through the centuries. The undoubted jewel in the crown of this extremely attractive gallery is an Annunciation by Antonello da Messina, a work which would be worth a visit alone.